Cleavage at the Furin Consensus Sequence RAR/KR and Presence of the Intervening Peptide of the Respiratory Syncytial Virus Fusion Protein Are Dispensable for Virus Replication in Cell Culture
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چکیده
Cleavage at the Furin Consensus Sequence RAR/KR and Presence of the Intervening Peptide of the Respiratory Syncytial Virus Fusion Protein Are Dispensable for Virus Replication in Cell Culture Gert Zimmer, Karl-Klaus Conzelmann, and Georg Herrler* Institut für Virologie, Tierärztliche Hochschule Hannover, D-30559 Hannover, and Max-von-Pettenkofer-Insitut and Genzentrum der Ludwig-Maximillians-Universität, D-81377 Munich, Germany
منابع مشابه
Cleavage at the furin consensus sequence RAR/KR(109) and presence of the intervening peptide of the respiratory syncytial virus fusion protein are dispensable for virus replication in cell culture.
Proteolytic processing of the respiratory syncytial virus F (fusion) protein results in the generation of the disulfide-linked subunits F1 and F2 and in the release of pep27, a glycopeptide originally located between the two furin cleavage sites FCS-1 (RKRR(136)) and FCS-2 (RAR/KR(109)). We made use of reverse genetics to study the importance of FCS-2 and of pep27 for BRSV replication in cell c...
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